Mixing GPT and MBR drives in one PC
I am contemplating a new PC (Win 8) and am thinking about one with a 4TB drive and a boot SSD. The big drive will obviously be formatted as GPT so I assume vendor (Dell) will also format SSD as GPT as well. I have 2 questions:
Is there a real-world difference in reliability or other factor that says get 2x2TB drives instead of 1x4TB drive?
If not, and I get the 4TB GPT-formatted drives, can I add another drive to the system that is MBR formatted. It would only be used for data. Can these two differently formatted HDDs co-exist peacefully or does it have to be all-or-nothing?